If this happens to you, stop taking zolpidem and talk with your doctor about another treatment for your sleep disorder. Phenibut may increase the central nervous system depressant CNS depressant activities of Zolpidem. C; cases of severe neonatal respiratory depression reported when zolpidem used near term, especially when taken with other CNS depressants Lactation: Do not open the pouch that contains the sublingual tablet Intermezzo until you are ready to take the tablet. Side Effects Dizziness may occur. The risk or severity of adverse effects can be increased when Zolpidem is combined with Desvenlafaxine. This is because the dosage of drug needed to cause muscle relaxation is 10 times the sedating dose, while early studies indicated that the dosage needed for preventing seizures is 20 times the sedating dose. Zolpidem para dormir profundamente
Co-administration with other CNS depressants e. Can cause drowsiness and a decreased level of consciousness, which may lead to falls and consequently to severe injuries; severe injuries such as hip fractures and intracranial hemorrhage have been reported. Abnormal thinking, behavioral changes, complex behaviors: Consider risk of respiratory depression before prescribing in patients with compromised regulatory functions.
Worsening of depression or suicidal thinking may occur; prescribe the least amount feasible to avoid intentional overdose. Use with caution and monitor closely in patients with hepatic impairment, mild to moderate COPD, impaired drug metabolism or hemodynamic responses, or mild to moderate sleep apnea. GABA agonists such as zolpidem tartrate have been associated with precipitation of hepatic encephalopathy in patients with hepatic insufficiency; patients with hepatic insufficiency do not clear zolpidem tartrate as rapidly as patients with normal hepatic function; avoid zolpidem use in patients with severe hepatic impairment as it may contribute to encephalopathy.
C; cases of severe neonatal respiratory depression reported when zolpidem used near term, especially when taken with other CNS depressants. Very low amounts secreted in breast milk; effect on infant unknown; use caution; advise mother to observe breastfeeding infant for lethargy, increased sedation, and changes in feeding habits. Controlled studies in pregnant women show no evidence of fetal risk.
Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. Positive evidence of human fetal risk. Do not use in pregnancy. Risks involved outweigh potential benefits. Imidazopyridine; modulates omega-1 type GABA receptor via selective antagonism, resulting in increased chloride conductance, neuronal hyperpolarization, inhibition of action potential, and a decrease in neuronal excitability that in turn produce sedative and hypnotic effects.
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Sign Up It's Free! If you log out, you will be required to enter your username and password the next time you visit. Brand and Other Names: Share Email Print Feedback Close. Schedule IV 5mg Ambien 10mg Ambien. Extended-release Ambien CR Women: Dosing considerations Ambien, Ambien CR Use lowest effective dose; take only once per night immediately before bedtime with at least hr remaining before the planned time of awakening In some patients, higher morning blood levels following use of 10 mg dose increase the risk of next day impairment of driving and other activities that require full alertness Total dose should not exceed 10 mg once daily immediately before bedtime; should be taken as single dose and should not be readministered during same night.
Insomnia Intermezzo Insomnia when a middle of the night awakening is followed by difficulty returning to sleep Women: Dosing Modifications Renal impairment Dose adjustment may not be necessary; monitor. Drug of choice when hypnotic indicated in elderly Insomnia Sleep initiation Immediate-release, oral spray: Insomnia Intermezzo Middle of the night awakening Men and women: Use lowest effective dose; take only once per night immediately before bedtime with at least hr remaining before the planned time of awakening Intermezzo: Significant - Monitor Closely.
All Interactions Sort By: Postmarketing reports Respiratory depression Sublingual tablet: Oral ulcers, blisters, and mucosal inflammation Liver and biliary system: Warnings Contraindications Contraindicated in patients with known hypersensitivity to zolpidem; observed reactions include anaphylaxis and angioedema. Cautions The risk of next-day psychomotor impairment, including impaired driving, is increased if taken with less than a full night of sleep remaining 7 to 8 hours ; if a higher than the recommended dose is taken; if co-administered with other CNS depressants or alcohol; or if co-administered with other drugs that increase blood levels of zolpidem; patients should be warned against driving and other activities requiring complete mental alertness if drug taken in these circumstances Co-administration with other CNS depressants e.
C; cases of severe neonatal respiratory depression reported when zolpidem used near term, especially when taken with other CNS depressants Lactation: However, this evaluation has shifted in the last few years as cases of addiction and habituation have accumulated. Zolpidem is recommended to be taken on a short-term basis only. Daily or continuous use of the drug is not usually advised. Zolpidem is a hypnotic nonbenzodiazepine drug of the imidazopyridine class. This class of drugs is named for having an imidazole constituent, a five-membered ring with two non-adjacent nitrogen constituents fused to a pyridine ring, a six-membered nitrogenous ring which shares a nitrogen with the imidazole group.
GABA A -agonizing imidazopyridines such as zolpidem are often grouped with pyrazolopyrimidines, and cyclopyrrones under the label "nonbenzodiazepines" for their similar effects. Zolpidem interacts with the GABA -BZ receptor system  and shares some of the pharmacological properties of traditional benzodiazepines. It's this selective binding in comparison to traditional benzodiazepines that gives zolpidem very weak anxiolytic , muscle relaxant , and anticonvulsant properties but very strong hypnotic or sedative properties.
As the GABA site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating or calming effects of zolpidem on the nervous system. In regards to how the consumption of this compound results in its bizarre hallucinations, the pharmacological mechanics behind this are not understood and do not seem to have been directly studied. It is worth noting, however, that zolpidem may share similar mechanisms as a GABA A receptor agonist to that of muscimol , which is the active compound within the hallucinogenic amanita muscaria mushroom.
It contains many of the physical and cognitive effects of benzodiazepines with a moderately dissociated headspace most similar to that of DXM. This occurs alongside bizarre thought patterns and external hallucinations similar to those of deliriants and visual distortions most similar to those of psychedelics. Overall, this makes zolpidem an extremely unique and unpredictable hallucinogen which requires a trip sitter. The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors.
The listed effects should be taken with a grain of salt and will rarely if ever occur all at once, but heavier doses will increase the chances and are more likely to induce a full range of effects. Likewise, adverse effects become much more likely on higher doses and may include serious injury or death. There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:.
Zolpidem has a low toxicity relative to dose. Zolpidem has been reported to cause psychosis , delusions and delirium at a significantly higher rate than other hallucinogens like LSD , ketamine , or DMT. There are a large number of experience reports online which describe states of delirium, amnesia, bizarre behavior,  sleep walking,  driving while impaired   and other serious consequences after abusing the drug.
In many cases this has resulted in hospitalization, arrests,  car crashes,  lengthy court cases and even death. It is strongly recommended that one use harm reduction practices and have a trip sitter when using this drug. Zolpidem is moderately addictive. A review of 36 human case reports found that reported dependence to zolpidem was lower than that of benzodiazepines.