Zolpidem medication information

By | 11.07.2018

zolpidem medication information

To take either brand of sublingual tablet, place the tablet under your tongue, and wait for it to dissolve. This medication may make you sleepy during the day. Zolpidem is for short-term use only. Read all patient information, medication guides, and instruction sheets provided to you. Place the tablet under your tongue and allow it to dissolve in your mouth without water. Some of these changes included decreased inhibition e. The following effects may happen:

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Zolpidem medication information Keep the medication in a place where others cannot get to it. Medication taking zolpidem and get emergency medical medication if you have any of these signs of an allergic reaction: Alcohol can make the side effects of zolpidem worse. This is normal and usually gets better without treatment after one or zolpidem nights. Do not take Information for middle-of-the-night insomnia unless you have 4 zolpidem of sleep information left before being active. Find out more here.

When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well. You may have trouble sleeping the first few nights after you stop taking this medication. This is called rebound insomnia and is normal. It will usually go away after nights. If this effect continues, contact your doctor. If this effect persists or worsens, tell your doctor or pharmacist promptly. This medication may make you sleepy during the day.

Tell your doctor if you have daytime drowsiness. Your dose may need to be adjusted. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake " sleep -driving".

Often, these people do not remember these events. This problem can be dangerous to you or to others. If you find out that you have done any of these activities after taking this medication, tell your doctor right away. Your risk is increased if you use alcohol or other medications that can make you drowsy while taking zolpidem. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction , including: This is not a complete list of possible side effects.

If you notice other effects not listed above, contact your doctor or pharmacist. Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Before taking zolpidem, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems.

Talk to your pharmacist for more details. Before using this medication , tell your doctor or pharmacist your medical history, especially of: Do not drive, use machinery, or do any activities that require clear thinking after you take this medication and the next day. You may feel alert, but this medication may continue to affect your thinking, making such activities unsafe. This medication may also increase the risk of falls. Alcohol or marijuana can make you more dizzy or drowsy.

Do not drink alcoholic beverages. Talk to your doctor if you are using marijuana. Children may be more sensitive to the side effects of this drug, especially dizziness and hallucinations. Older adults may be more sensitive to the side effects of this drug, especially dizziness, confusion, unsteadiness, and excessive drowsiness. These side effects can increase the risk of falling. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs , nonprescription drugs, and herbal products.

During pregnancy , this medication should be used only when clearly needed. Infants born to mothers who have taken sedative-hypnotics near the time of delivery may have undesirable effects such as breathing problems or withdrawal symptoms. Discuss the risks and benefits with your doctor. A small amount of this medication passes into breast milk.

Consult your doctor before breast -feeding. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. A product that may interact with this drug is: Other medications can affect the removal of zolpidem from your body, which may affect how zolpidem works.

Examples include azole antifungals such as ketoconazole , rifampin , St. John's Wort, among others. Tell your doctor or pharmacist if you are taking other products such as opioid pain or cough relievers such as codeine, hydrocodone , alcohol, marijuana , other drugs for sleep or anxiety such as alprazolam , lorazepam , zopiclone , muscle relaxants such as carisoprodol , cyclobenzaprine , or antihistamines such as cetirizine , diphenhydramine.

Check the labels on all your medicines such as allergy or cough -and-cold products because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely. If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away.

Combined with alcohol, opiates, or other CNS depressants, it may be even more likely to lead to fatal overdoses. Zolpidem overdosage can be treated with the benzodiazepine receptor antagonist flumazenil , which displaces zolpidem from its binding site on the benzodiazepine receptor to rapidly reverse the effects of the zolpidem. Zolpidem may be quantitated in blood or plasma to confirm a diagnosis of poisoning in hospitalized patients, provide evidence in an impaired driving arrest, or to assist in a medicolegal death investigation.

Analytical techniques, in general, involve gas or liquid chromatography. Use of zolpidem may impair driving skills with a resultant increased risk of road traffic accidents. This adverse effect is not unique to zolpidem but also occurs with other hypnotic drugs. Caution should be exercised by motor vehicle drivers. As a consequence, the FDA recommended the dose for women be reduced and that prescribers should consider lower doses for men. The elderly are more sensitive to the effects of hypnotics including zolpidem.

Zolpidem causes an increased risk of falls and may induce adverse cognitive effects. An extensive review of the medical literature regarding the management of insomnia and the elderly found that there is considerable evidence of the effectiveness and durability of nondrug treatments for insomnia in adults of all ages, and these interventions are underused.

Compared with the benzodiazepines, the nonbenzodiazepine including zolpidem sedative-hypnotics appeared to offer few, if any, significant clinical advantages in efficacy or tolerability in elderly persons. Newer agents with novel mechanisms of action and improved safety profiles, such as the melatonin receptor agonists , were found to hold promise for the management of chronic insomnia in elderly people.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment anterograde amnesia , daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls. In addition, the effectiveness and safety of long-term use of these agents remain to be determined. More research is needed to evaluate the long-term effects of treatment and the most appropriate management strategy for elderly persons with chronic insomnia.

Patients suffering from gastroesophageal reflux disease GERD had reflux events measured to be significantly longer when taking zolpidem than on placebo. The same trend was found for reflux events in patients without GERD. This is assumed to be due to suppression of arousal during the reflux event, which would normally result in a swallowing reflex to clear gastric acid from the esophagus.

Patients with GERD experience significantly higher esophageal exposure to gastric acid, which increases the likelihood of their developing esophageal cancer. Zolpidem has been assigned to pregnancy category C by the FDA. Animal studies have revealed evidence of incomplete ossification and increased postimplantation fetal loss at doses greater than seven times the maximum recommended human dose or higher; however, teratogenicity was not observed at any dose level.

There are no controlled data in human pregnancy. In one case report, zolpidem was found in cord blood at delivery. Zolpidem is recommended for use during pregnancy only when benefits outweigh risks. Accordingly, it has strong hypnotic properties and weak anxiolytic , myorelaxant , and anticonvulsant properties. Like zaleplon , zolpidem may increase slow wave sleep but cause no effect on stage 2 sleep. Three syntheses of zolpidem are common.

This is brominated and reacted with 2-aminomethylpyridine to give the imidazopyridine. From here the reactions use a variety of reagents to complete the synthesis, either involving thionyl chloride or sodium cyanide. These reagents are challenging to handle and require thorough safety assessments. A number of major side-products of the sodium cyanide reaction have been characterised and include dimers and mannich products.

Notable drug—drug interactions with the pharmacokinetics of zolpidem include chlorpromazine , fluconazole , imipramine , itraconazole , ketoconazole , rifampicin , and ritonavir. Interactions with carbamazepine and phenytoin can be expected based on their metabolic pathways, but have not yet been studied. There does not appear to be any interaction between zolpidem and cimetidine or ranitidine.

Zolpidem is one of the most common GABA -potentiating sleeping medications prescribed in the Netherlands , with a total of , prescriptions dispensed in The United States Air Force uses zolpidem as one of the hypnotics approved as a " no-go pill " with a 6-hour restriction on subsequent flight operation to help aviators and special duty personnel sleep in support of mission readiness. The other hypnotics used are temazepam and zaleplon.

Zolpidem has potential for either medical misuse when the drug is continued long term without or against medical advice, or for recreational use when the drug is taken to achieve a "high". Chronic users of high doses are more likely to develop physical dependence on the drug, which may cause severe withdrawal symptoms, including seizures, if abrupt withdrawal from zolpidem occurs. Other drugs, including the benzodiazepines and zopiclone , are also found in high numbers of suspected drugged drivers.

Kennedy says that he was using Zolpidem Ambien and Phenergan when caught driving erratically at 3 am. Nonmedical use of zolpidem is increasingly common in the U. Some users have reported decreased anxiety, mild euphoria , perceptual changes, visual distortions, and hallucinations. For the stated reason of its potential for recreational use and dependence, zolpidem along with the other benzodiazepine-like Z-drugs is a Schedule IV substance under the Controlled Substances Act in the U.

The United States patent for zolpidem was held by the French pharmaceutical corporation Sanofi-Aventis. Zolpidem has become one of many date rape drugs. Zolpidem received widespread media coverage in Australia after the death of a student who fell 20 m from the Sydney Harbour Bridge while under the influence of zolpidem. While cases of zolpidem improving aphasia in people with stroke have been described, use for this purpose has unclear benefit. Media related to Zolpidem at Wikimedia Commons.

From Wikipedia, the free encyclopedia. C Risk not ruled out. S4 Prescription only CA: Retrieved 15 March FDA approves new label changes and dosing for zolpidem products and a recommendation to avoid driving the day after using Ambien CR". Journal of medical toxicology: Retrieved 3 April BMJ Clinical research ed. Retrieved 5 February Neuropharmacological and behavioral effects".

Zolpidem and sleep-related behaviours A review of the literature on sleep related disorders and abnormal sexual behaviors and experiences". Archived from the original on The Journal of Clinical Psychiatry. J Am Pharm Assoc Wash. Psychiatr Prax in German. J Assoc Physicians India. Journal of Addictive Diseases.

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