Disclosure forms provided by the authors are available with the full text of this article at NEJM. Patients were excluded if they were previously prescribed zolpidem at any time through the CU health system. We comply with the HONcode standard for trustworthy health information - verify here. Characteristics of the study population before and after the zolpidem labeling change. Am J Public Health ;
Drug of choice when hypnotic indicated in elderly Insomnia Sleep initiation Immediate-release, oral spray: Insomnia Intermezzo Middle of the night awakening Men and women: Use lowest effective dose; take only once per night immediately before bedtime with at least hr remaining before the planned time of awakening Intermezzo: Significant - Monitor Closely.
All Interactions Sort By: Postmarketing reports Respiratory depression Sublingual tablet: Oral ulcers, blisters, and mucosal inflammation Liver and biliary system: Warnings Contraindications Contraindicated in patients with known hypersensitivity to zolpidem; observed reactions include anaphylaxis and angioedema. Cautions The risk of next-day psychomotor impairment, including impaired driving, is increased if taken with less than a full night of sleep remaining 7 to 8 hours ; if a higher than the recommended dose is taken; if co-administered with other CNS depressants or alcohol; or if co-administered with other drugs that increase blood levels of zolpidem; patients should be warned against driving and other activities requiring complete mental alertness if drug taken in these circumstances Co-administration with other CNS depressants e.
C; cases of severe neonatal respiratory depression reported when zolpidem used near term, especially when taken with other CNS depressants Lactation: Very low amounts secreted in breast milk; effect on infant unknown; use caution; advise mother to observe breastfeeding infant for lethargy, increased sedation, and changes in feeding habits Pregnancy Categories A: Pharmacology Mechanism of Action Imidazopyridine; modulates omega-1 type GABA receptor via selective antagonism, resulting in increased chloride conductance, neuronal hyperpolarization, inhibition of action potential, and a decrease in neuronal excitability that in turn produce sedative and hypnotic effects.
Elimination Half-life Immediate release: Administration Oral Administration Extended-release tablet: Swallow whole; do not chew, crush, or split. Print without Office Info. Print with Office Info. Formulary Formulary Patient Discounts. Create Your List of Plans. View explanations for tiers and restrictions. Tier Description 1 This drug is available at the lowest co-pay.
Most commonly, these are generic drugs. Most commonly, these are "preferred" on formulary brand drugs. Most commonly, these are "non-preferred" brand drugs. Most commonly, these are "non-preferred" brand drugs or specialty prescription products. This restriction requires that specific clinical criteria be met prior to the approval of the prescription.
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Advise patients to place the tablet under the tongue and allow it to disintegrate completely; this dose form should not be swallowed whole or taken with water. Advise patients to remove the tablet from the pouch just prior to dosing. Consult the manufacturer product information for management recommendations. Insomnia melatonin , lorazepam , amitriptyline , zolpidem , Ambien , Ativan , diphenhydramine , temazepam , doxepin , Elavil , Restoril , Lunesta , Ibuprofen PM , eszopiclone , Belsomra , Rozerem , triazolam , zaleplon , ramelteon , Sonata , doxylamine , Halcion , Silenor , flurazepam , More The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.
Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. To view content sources and attributions, please refer to our editorial policy. We comply with the HONcode standard for trustworthy health information - verify here. Applies to the following strengths: Usual Adult Dose for: Insomnia Usual Geriatric Dose for: Insomnia Usual Pediatric Dose for: Insomnia Additional dosage information: Print this page Add to My Med List.