Please share your positive and negative experiences with the drug, and compare it with other treatments you have used. Inform patients that impairment can be present despite feeling fully awake. Nonetheless, the emergence of any new behavioral sign or symptom of concern requires careful and immediate evaluation. This Site and third parties who place advertisements on this Site may collect and use information about your visits to this Site and other websites in order to provide advertisements about goods and services of interest to you. I have no side effects, unlike the over the counter sleep aids that did not help with sleeplessness but caused drowsiness the next day. In mice, these doses are approximately 2. Gargled cold water, spit it out a few times.
I suffered from insomnia for years before discovering Ambien. I have been taking 5mg maybe 3 times a week as needed chit fifteen years now. Never had any freaky side effects but believe it has impacted by short term memory and can me a little groggy in the morning sometimes, but it quickly dissipates. I highly recommend this drug for people who suffer insomnia, love it! Initially, I tried 10mg but the dose was too strong so I broke the pill in half.
I've tried so many over the counter sleep aids, and doctor prescribed various anti-anxiety pills with no success anti-anxiety pills caused bad headaches. Zolpidem helps me fall asleep and stay asleep for at least 7 hours. I have no side effects, unlike the over the counter sleep aids that did not help with sleeplessness but caused drowsiness the next day. With a very busy life and menopause, Zolpidem really helps me get the sleep I need.
We are all different works for some but not others but it's worth giving it a try. Rated Ambien Zolpidem for Insomnia Report I was on ambien 10 years, this medication worked great for me but i had temporarily amnesia and would do many things in my sleep. My brain doesn't like to "shut down" without the ambien i would fall asleep at 4 am or so if i fell asleep at all so my doctor put me on it at Over the years i would sleep clean my house, i would wake up and my home was spotless, i would sleep eat and i would even have sex in my sleep.
Most of the time i wouldn't remember at all unless my spouse or something triggered a memory. It made me for lack of a better term very "horny". My mother and sister complain of the same thing. This does do wonders to help you fall asleep though. About 7 yrs ago I could not go to sleep or if I did, I could not stay asleep. Overall, I love my little pill and take extra measures to never be without one. Rated Ambien Zolpidem for Insomnia Report My husband took this for a brief period of time we made him get off of it.
He woke our boys up at 5: He had other periods of doing things in the early morning and not knowing what he was doing. Almost like he was sleepwalking. I would never take the chance with this drug. I have heard too many horror stories about people doing things and not remembering they did it the next day. Rated Ambien Zolpidem for Insomnia Report I have taken this drug for 13 years and use to get a good nights sleep as i am a company director and have a lot of things on my mind when I lay in bed trying to get to sleep.
I have a happy family life with no probs. Rated Ambien Zolpidem for Insomnia Report I've been taking 5 mg of Ambien approximately 5 to 6 nights a week for the last year and a half. It works great for me. The only side effects I've noticed are a loss of coordination but it's very mild. Also some mild memory problems. For me, the mild side effects are well worth being able to sleep at night. Tell patients to wait for at least 8 hours after dosing before driving or engaging in other activities requiring full mental alertness.
Inform patients that impairment can be present despite feeling fully awake. Inform patients that severe anaphylactic and anaphylactoid reactions have occurred with zolpidem. Instruct patients and their families that sedative hypnotics can cause abnormal thinking and behavior change, including "sleep driving" and other complex behaviors while not being fully awake preparing and eating food, making phone calls, or having sex.
Tell patients to call you immediately if they develop any of these symptoms. Ask patients about alcohol consumption, medicines they are taking, and drugs they may be taking without a prescription. Tell patients not to increase the dose of AMBIEN on their own, and to inform you if they believe the drug "does not work". Patients should be counseled to take AMBIEN right before they get into bed and only when they are able to stay in bed a full night 7—8 hours before being active again.
In mice, these doses are approximately 2. No evidence of carcinogenic potential was observed in mice. In rats, renal tumors lipoma , liposarcoma were seen at the mid- and high doses. Zolpidem was negative in in vitro bacterial reverse mutation, mouse lymphoma , and chromosomal aberration and in vivo mouse micronucleus genetic toxicology assays. There was no impairment of fertility at any dose tested. Studies in children to assess the effects of prenatal exposure to zolpidem have not been conducted; however, cases of severe neonatal respiratory depression have been reported when zolpidem was used at the end of pregnancy, especially when taken with other CNS-depressants.
Children born to mothers taking sedative-hypnotic drugs may be at risk for withdrawal symptoms during the postnatal period. Neonatal flaccidity has also been reported in infants born to mothers who received sedativehypnotic drugs during pregnancy. AMBIEN should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus. Zolpidem is excreted in human milk. Safety and effectiveness of zolpidem in pediatric patients below the age of 18 years have not been established.
Ten patients on zolpidem 7. A total of patients in U. For a pool of U. Women clear zolpidem tartrate from the body at a lower rate than men. Given the higher blood levels of zolpidem tartrate in women compared to men at a given dose, the recommended initial dose of AMBIEN for adult women is 5 mg, and the recommended dose for adult men is 5 or 10 mg. In geriatric patients, clearance of zolpidem is similar in men and women. The recommended dose of AMBIEN in patients with mild to moderate hepatic impairment is 5 mg once daily immediately before bedtime.
General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. As in all cases of drug overdose, respiration , pulse , blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following zolpidem overdosage, even if excitation occurs.
The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that zolpidem is not dialyzable. As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.
Zolpidem, the active moiety of zolpidem tartrate, is a hypnotic agent with a chemical structure unrelated to benzodiazepines , barbiturates, or other drugs with known hypnotic properties. It interacts with a GABA-BZ receptor complex and shares some of the pharmacological properties of the benzodiazepines.
In contrast to the benzodiazepines, which non-selectively bind to and activate all BZ receptor subtypes, zolpidem in vitro binds the BZ 1 receptor preferentially with a high affinity ratio of the a subunits. This selective binding of zolpidem on the BZ 1 receptor is not absolute, but it may explain the relative absence of myorelaxant and anticonvulsant effects in animal studies as well as the preservation of deep sleep stages 3 and 4 in human studies of zolpidem tartrate at hypnotic doses.
In a single-dose crossover study in 45 healthy subjects administered 5 and 10 mg zolpidem tartrate tablets, the mean peak concentrations Cmax were 59 range: Total protein binding was found to be Zolpidem did not accumulate in young adults following nightly dosing with 20 mg zolpidem tartrate tablets for 2 weeks. A food-effect study in 30 healthy male subjects compared the pharmacokinetics of AMBIEN 10 mg when administered while fasting or 20 minutes after a meal.
The half-life remained unchanged. These results suggest that, for faster sleep onset, AMBIEN should not be administered with or immediately after a meal. The pharmacokinetics of AMBIEN in eight patients with chronic hepatic insufficiency were compared to results in healthy subjects. Following a single 20 mg oral zolpidem tartrate dose, mean Cmax and AUC were found to be two times vs. Tmax did not change. The mean half-life in cirrhotic patients of 9.
No statistically significant differences were observed for Cmax, Tmax, half-life, and AUC between the first and last day of drug administration when baseline concentration adjustments were made. Zolpidem was not hemodialyzable. No accumulation of unchanged drug appeared after 14 or 21 days. Zolpidem pharmacokinetics were not significantly different in renally impaired patients. No dosage adjustment is necessary in patients with compromised renal function.
Similarly, chlorpromazine in combination with zolpidem produced no pharmacokinetic interaction, but there was an additive effect of decreased alertness and psychomotor performance. The lack of a drug interaction following single-dose administration does not predict the absence of an effect following chronic administration. Following five consecutive nightly doses at bedtime of oral zolpidem tartrate 10 mg in the presence of sertraline 50 mg 17 consecutive daily doses, at 7: Pharmacokinetics of sertraline and N-desmethylsertraline were unaffected by zolpidem.
A single-dose interaction study with zolpidem tartrate 10 mg and fluoxetine 20 mg at steady-state levels in male volunteers did not demonstrate any clinically significant pharmacokinetic or pharmacodynamic interactions. Some compounds known to inhibit CYP3A may increase exposure to zolpidem. The effect of inhibitors of other P enzymes on the pharmacokinetics of zolpidem is unknown.
There were no pharmacodynamic effects of zolpidem detected on subjective drowsiness, postural sway, or psychomotor performance. Zolpidem tartrate had no effect on digoxin pharmacokinetics and did not affect prothrombin time when given with warfarin in healthy subjects. Both zolpidem doses were superior to placebo on objective polysomnographic measures of sleep latency, sleep duration, and number of awakenings. All zolpidem doses were superior to placebo on the two primary PSG parameters sleep latency and efficiency and all four subjective outcome measures sleep duration, sleep latency, number of awakenings, and sleep quality.
On objective polysomnographic measures of sleep latency and sleep efficiency, zolpidem 10 mg was superior to placebo on sleep latency for the first 4 weeks and on sleep efficiency for weeks 2 and 4. Zolpidem was comparable to placebo on number of awakenings at both doses studied. Zolpidem 10 mg was superior to placebo on a subjective measure of sleep latency for all 4 weeks, and on subjective measures of total sleep time, number of awakenings, and sleep quality for the first treatment week.
Increased wakefulness during the last third of the night as measured by polysomnography has not been observed in clinical trials with AMBIEN. In three studies in adults including one study in a phase advance model of transient insomnia and in one study in elderly subjects, a small but statistically significant decrease in performance was observed in the Digit Symbol Substitution Test DSST when compared to placebo. There was no objective polysomnographic evidence of rebound insomnia at recommended doses seen in studies evaluating sleep on the nights following discontinuation of AMBIEN zolpidem tartrate.
There was subjective evidence of impaired sleep in the elderly on the first post-treatment night at doses above the recommended elderly dose of 5 mg. Controlled studies in adults utilizing objective measures of memory yielded no consistent evidence of next-day memory impairment following the administration of AMBIEN. However, in one study involving zolpidem doses of 10 and 20 mg, there was a significant decrease in next-morning recall of information presented to subjects during peak drug effect 90 minutes post-dose , i.
There was also subjective evidence from adverse event data for anterograde amnesia occurring in association with the administration of AMBIEN, predominantly at doses above 10 mg. In studies that measured the percentage of sleep time spent in each sleep stage, AMBIEN has generally been shown to preserve sleep stages. Sleep time spent in stages 3 and 4 deep sleep was found comparable to placebo with only inconsistent, minor changes in REM paradoxical sleep at the recommended dose.
There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Call your healthcare provider right away if you find out that you have done any of the above activities after taking AMBIEN. AMBIEN is used in adults for the short-term treatment of a sleep problem called insomnia trouble falling asleep.
Tell your healthcare provider if you have ever abused or have been dependent on alcohol, prescription medicines or street drugs. Tell your healthcare provider about all of the medicines you take , including prescription and nonprescription medicines, vitamins and herbal supplements. Medicines can interact with each other, sometimes causing serious side effects. Know the medicines you take. Keep a list of your medicines with you to show your healthcare provider and pharmacist each time you get a new medicine.
Call your healthcare provider right away if you have any of the above side effects or any other side effects that worry you while using AMBIEN. Ask your healthcare provider or pharmacist for more information. Call your healthcare provider for medical advice about side effects. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. It may harm them and it is against the law.
If you would like more information, talk with your healthcare provider.